| Manufacturer | Healing Pharma India Pvt. Ltd. |
| Prescription/Non prescription | Prescription |
| Brand | Healing Pharma India Pvt Ltd |
Perindopril Erbumine (Coverheal 4) 4 mg tablet is a nonsulfhydryl prodrug that is an angiotensin-converting enzyme (ACE) inhibitor used to keep your blood pressure under control. It helps relax your blood vessels, consequently lowering your blood pressure. It may also be used to treat other conditions such as heart failure and disorders of the blood vessels of the heart.
Drug =Perindopril Erbumine
Number of Pills Per Order = 10
Strength = 4 mg
Manufacturer = Healing Pharma
How To Take
This medicine should be taken on an empty stomach 30 minutes before your meal. Try to take it at the same time each day.
Perindopril must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed otherwise, as stopping it suddenly may worsen your condition.
Take Perindopril precisely as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Dosage of Perindopril Erbumine (Coverheal 4) 4 mg
Adult: Hypertension: As perindopril erbumine: Initial: 4 mg once daily, may be titrated according to clinical response. Maximum dose of 8 mg/day. As perindopril arginine: Initial: 5 mg once daily, may be titrated according to clinical response. Maximum dose of 10 mg/day.
Heart failure: As perindopril erbumine: Initial: 2 mg once daily, preferably in the morning, may adjust according to clinical response. Usual maintenance dose: 4 mg once daily. As perindopril arginine: Initial: 2.5 mg once daily, preferably in the morning, may adjust dosage according to clinical response. Usual maintenance dose: 5 mg once daily.
Stable coronary artery disease: As perindopril erbumine: Initial: 4 mg once daily for two weeks, maybe titrated according to clinical response. Max dose: 8 mg/day. As perindopril arginine: Initial: 5 mg once daily for two weeks, maybe titrated according to clinical response. Maximum dose of 10 mg/day.
Missed Dose
If you miss a dose, skip the missed dose and return to your usual dosing schedule. If you often forget to take your medicine, let your doctor and pharmacist know.
Do not double a dose under any circumstances.
Overdose of Perindopril Erbumine (Coverheal 4) 4 mg
Signs of overdose may include the following:
- Hypotension
- Bradycardia
- Circulatory shock
- Renal failure
- Hyperventilation
- Electrolyte disturbances
- Tachycardia
- Palpitations
- Dizziness
- Anxiety
- Cough
Seek medical help immediately.
Contraindications
People with the following medical conditions should not take Perindopril Erbumine:
- History of angioedema related to previous ACE inhibitor treatment
- Hereditary or idiopathic angioedema
- Bilateral or unilateral renal stenosis
- Patients with extracorporeal treatments leading to contract of blooding with negatively charged surfaces
- Concomitant use with aliskiren especially in a patient with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m2)
- Concomitant use with sacubitril/valsartan
- Pregnancy and lactation
Side Effects
Perindopril Erbumine may have the following side effects:
- Cholestatic jaundice
- Hypotension
- Syncope
- Hyperkalemia
- Cough
- Neutropenia
- Agranulocytosis
- Anemia
- Thrombocytopenia
- Palpitations
- Tachycardia
- Tinnitus
- Visual disturbance
- Nausea
- Constipation
- Diarrhea
- Dyspepsia
- Vomiting
- Abdominal pain
- Asthenia
- Peripheral edema
- Urticaria
- Elevated BUN
- Increased serum creatinine
- Increased serum bilirubin
- Muscle cramps
- Headache
- Paresthesia
- Vertigo
- Dysgeusia
- Dizziness
- Mood disturbances
- Sleep disorders
- Renal insufficiency
- Proteinuria
- Erectile dysfunction
- Dyspnea
- Bronchospasm
- Pruritus
- Rash
- Vasculitis
- Flushing
- Impaired peripheral circulation
- Epistaxis
- Raynaud’s phenomenon
Potentially Fatal:
- Angioedema
- Arrhythmia
- Rarely, fulminant hepatic necrosis.
Warnings
Do not use Perindopril in people with the following conditions:
- A serious allergic reaction which causes swelling of the face, lips and throat due to an unknown reason or a family history
- Pregnancy
Inform your doctor and pharmacist if you are taking any of these medicines:
- Alikserin
- Sacubitril
- Valsartan
- Losartan
- Prazosin
- Hydralazine
- Nitroglycerin
- Isosorbide mononitrate
- Isosorbide dinitrate
- Insulin
- Metformin
- Gliclazide
- Sitagliptin
- Aspirin
- Diclofenac
- Indometacin
- Everolimus
- Sirolimus
- Temsirolimus
- Lithium
- Potassium supplements
Inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and non-prescription medicines.
This list does not include all medicines that may interact with Perindopril.
How Does Perindopril Erbumine (Coverheal 4) 4 mg Work?
Perindopril is a prodrug of perindoprilat, an angiotensin-converting enzyme inhibitor which prevents the conversion of angiotensin I to angiotensin II, thereby increasing the activity of plasma renin and decreasing vasoconstriction and secretion of aldosterone.
Uses
Perindopril Erbumine is used to treat the following conditions:
- Hypertension
- Heart failure
- Stable coronary artery disease
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Patient with hypertrophic cardiomyopathy with outflow tract obstruction
- Salt or volume depletion
- Collagen vascular disease (e.g. SLE, scleroderma)
- The severe mitral valve and aortic stenosis
- Ascites due to cirrhosis
- Refractory ascites
- Diabetes
- Primary aldosteronism
- Cardiovascular disease (e.g. ischaemic heart disease)
- Patients undergoing major surgery or during anaesthesia
- Black race
- Desensitisation treatment (e.g. Hymenoptera venom)
- Renal and hepatic impairment
- Elderly
- Avoid alcohol
- Cut down on your salt intake. This may help lower your blood pressure and improve your overall health. Speak to your doctor or dietitian about ways to cut down on your salt intake.
Storage Conditions
- Store between 20-25°C. Protect from light and moisture.
- Store in a cool, dry place away from the reach of children.
- Do not use perindopril that is expired or out of date.
