Glimepiride 4mg (Healmaryl 4) 4 mg tablet is an oral diabetes medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus but not for treating type 1 diabetes.
Drug = Glimepiride 4mg
Strength = 4 mg
Manufacturer = Healing Pharma
How To Take
This medicine should be taken before your first main meal of the day. Do not skip your meals after taking this medicine.
Glimepiride must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take Glimepiride precisely as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Dosage
Adult: Initial: 1 mg daily, may increase in increments of 1 mg at intervals of 1-2 weeks according to the response. Maintenance: 4 mg/day. Maximum of 6 mg/day.
Missed Dose
If you miss a dose, skip the missed dose and return to your usual dosing schedule. If you often forget to take your medicine, let your doctor and pharmacist know.
Do not double a dose under any circumstances.
Overdose
Signs of overdose may include the following:
- Nausea
- Vomiting
- Epigastric pain
- Hypoglycemia
- Restlessness
- Tremor
- Visual disturbances
- Coordination problems
- Sleepiness
- Coma
- Convulsions
Seek medical help immediately.
Contraindications
People with the following medical conditions should not take Glimepiride:
- Hypersensitivity to Glimepiride
- Sulfonylureas or sulfonamides
- Type 1 diabetes or insulin-dependent diabetes, and diabetic ketoacidosis (with or without coma)
- Severe renal or hepatic impairment
Side Effects
Glimepiride may have the following side effects:
- Hypoglycemia
- Hemolytic anemia (in G6PD deficiency)
- Hypersensitivity reaction (e.g., anaphylaxis, angioedema, Stevens-Johnson syndrome)
- Weight gain
- Leukopenia
- Agranulocytosis
- Aplastic anemia
- Pancytopenia
- Thrombocytopenia
- Inappropriate antidiuretic hormone secretion (SIADH).
- Visual disturbances
- Abdominal pain
- Diarrhea
- Nausea
- Vomiting
- Dysgeusia
- Asthenia
- Cholestasis
- Jaundice
- Hepatitis
- Liver failure
- Hepatic porphyria
- Disulfiram-like reactions
- Hyponatremia
- Headache
- Dizziness
- Photosensitivity
- Alopecia
Warnings
Do not use Glimepiride in people with the following conditions:
- Allergic reactions to similar sulfonamides or sulfonylureas such as glipizide, tolbutamide, sulfamethoxazole, or sulfasalazine.
- Type 1 diabetes
- Severe kidney disease
- Severe liver disease
- Complications of diabetes (diabetic ketoacidosis and diabetic coma)
Inform your doctor and pharmacist if you are taking or using any of these medicines:
- Miconazole
- Fluconazole
- Insulin
- Metformin
- Rifampicin
- Isoniazid
- Anabolic steroids
- Chloramphenicol
- Clarithromycin
- Phenytoin
- Barbiturates
- Albuterol
- Terbutaline
- Cyclophosphamide
- Fibrates
- Phenylbutazone
- Aspirin
- Warfarin
- Disopyramide
- Metoprolol
- Diazoxide
- Fluoxetine
- Chlorpromazine
- Allopurinol
- Probenecid
- Thiazide diuretics
- Birth control pills
Inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and non-prescription medicines.
This list does not include all medicines that may interact with Glimepiride.
How Does It Work?
Glimepiride is an antidiabetic sulphonylurea which reduces blood glucose levels by stimulating the release of insulin from pancreatic beta-cells and decreases glucose output from the liver. It also increases insulin sensitivity at peripheral target sites.
Uses
Glimepiride is used to treat the following conditions:
- Type 2 diabetes mellitus
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Patient with G6PD deficiency
- Stress-related states (e.g., fever, trauma, infection, surgery)
- Mild to moderate renal and hepatic impairment
- Elderly
- Pregnancy and lactation
- Avoid alcohol
- It is essential to maintain a healthy diet and weight to help keep your diabetes under control.
Storage Conditions
- Store below 30°C. Protect from moisture.
- Store in a cool, dry place away from the reach of children.
- Do not use Glimepiride that is expired or out of date.
