Ranoheal 500 | Ranolazine 500mg – 10 Tablets

Ranolazine (Ranoheal 500) 500 mg tablet is a piperazine derivative used to treat chronic angina, a long-term chest pain which occurs when the heart does not receive enough blood and oxygen.

Drug =Ranolazine

Number of Pills Per Order = 10

Strength = 500 mg

Manufacturer = Healing Pharma

How To Take

This medicine may be taken with or without food. Try to take it at the same time each day.

Ranolazine is available as an extended-release tablet. Swallow it whole. Do not crush, break, or chew the tablet.

Take Ranolazine precisely as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Dosage  of Ranolazine (Ranoheal 500) 500 mg

Adult: Initial: 375 mg twice a day, then 500 mg twice a day after 2-4 weeks. Maximum dose of 750 mg twice a day.

Missed Dose

If you miss a dose, skip the missed dose and return to your usual dosing schedule. If you often forget to take your medicine, let your doctor and pharmacist know.

Do not double a dose under any circumstances.

Overdose of Ranolazine (Ranoheal 500) 500 mg

Signs of overdose may include the following:

• Dizziness
• Nausea
• Vomiting
• Diplopia
• Lethargy
• Syncope
• Severe tremor
• Incoordination
• Dysplasia
• Hallucination

Seek medical help immediately.

Contraindications

People with the following medical conditions should not take Ranolazine:

• Concomitant admin w/ potent CYP3A4 inhibitors
• CYP3A4 inducers and class 1A or class III antiarrhythmics other than amiodarone
• Moderate to severe hepatic and severe renal impairment (CrCl <30 mL/min).

Side Effects

Ranolazine may have the following side effects:

• QT interval prolongation
• Acute renal failure
• Nausea
• Constipation
• Dizziness
• Headache
• Palpitations
• Tinnitus
• Vertigo
• Dry mouth
• Abdominal pain
• Vomiting
• Peripheral oedema
• Dyspnea
• Bradycardia
• Haematuria
• Paraesthesia
• Hypotension
• Blurred vision

Warnings

Do not use Ranolazine in people with the following conditions:

• Moderate or severe liver disease
• Severe kidney disease
• A sudden episode of chest pain

Inform your doctor and pharmacist if you are taking any of these medicines:

• Clarithromycin
• Telithromycin
• Itraconazole
• Ketoconazole
• Voriconazole
• Posaconazole
• Ritonavir
• Saquinavir
• Nefazodone
• Quinidine
• Dofetilide
• Sotalol
• Phenytoin
• Carbamazepine
• Phenobarbital
• Rifampicin
• St. John’s wort
• Erythromycin
• Fluconazole
• Digoxin
• Metoprolol
• Diltiazem
• Verapamil
• Terfenadine
• Astemizole
• Misolastine
• Imipramine
• Doxepin
• Amitriptyline
• Efavirenz
• Lovastatin
• Simvastatin
• Ciclosporin
• Tacrolimus
• Cyclophosphamide

Inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and non-prescription medicines.

This list does not include all medicines that may interact with Ranolazine.

How Does Ranolazine (Ranoheal 500) 500 mg  Work?

Ranolazine exerts its antianginal and anti-ischemic effects through inhibition of concentration-, voltage-, and frequency-dependent late sodium current and other cardiac ion channels and transporters. It may decrease the magnitude of the late sodium current resulting in a net reduction in intracellular sodium concentrations, a reversal of calcium overload, restoration of ventricular pump function, and prevention of ischemia-induced arrhythmias.

Uses 

Ranolazine is used  to treat the following conditions:

• Stable angina.

Special Precautions and Connected Warnings

Take special precautions if you have the following conditions:

• Patient w/ history of long QT syndrome
• Known acquired QT interval prolongation
• Moderate to severe CHF (NYHA Class III-IV)
• Low wt (<60 kg). Mild hepatic and mild to moderate renal impairment (CrCl 30-80 mL/min)
• Elderly
• Pregnancy and lactation
• Avoid alcohol and grapefruit or grapefruit juice.

Storage Conditions

• Store at 25°C.
• Store in a cool, dry place away from the reach of children.
• Do not use Ranolazine that is expired or out of date.