Leflunomide (Lefuheal 20 mg) 20 mg tablet is a pyrimidine synthesis inhibitor used to treat rheumatoid arthritis. It helps reduce pain and swelling in your joints. It is also used to treat psoriatic arthritis, a condition characterized by inflammation of the joints associated with psoriasis.
Drug =Leflunomide
Number of Pills Per Order = 10
Strength = 20 mg
Manufacturer = Healing Pharma
How To Take
This medicine may be taken with or without food. Take Leflunomide with plenty of water. Try to make it at the same time each day.
Leflunomide must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take Leflunomide exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Dosage Leflunomide (Lefuheal 20 mg) 20 mg
Adult: Rheumatoid arthritis; Psoriatic arthritis: Loading dose: 100 mg once daily for three days. Maintenance: 10-20 mg once daily.
Missed Dose
If you miss a dose, skip the missed dose and return to your usual dosing schedule. If you often forget to take your medicine, let your doctor and pharmacist know.
Do not double a dose under any circumstances.
Overdose of Leflunomide (Lefuheal 20 mg) 20 mg
Signs of overdose may include the following:
- Abdominal pain
- Nausea
- Diarrhea
- Elevated liver enzymes
- Anemia
- Leucopenia
- Pruritus and rash
Seek medical help immediately.
Contraindications
People with the following medical conditions should not take Leflunomide:
- Hepatic impairment
- Moderate and severe renal impairment
- Compromised immune function including bone marrow dysplasia or severe uncontrolled infection
- Severe hypoproteinaemia; concurrent vaccination w/ live vaccines
- Pregnancy and lactation
Side Effects
Leflunomide may have the following side effects:
- Hypertension
- Diarrhea
- Upper respiratory tract infections
- Thrombocytopenia
- Leukopenia
- Pancytopenia
- Agranulocytosis
- Headache
- Alopecia
- Dry skin
- Eczema
Erythema multiforme - Hypokalemia
- Weight loss
- Asthenia
- Anxiety
- Paraesthesia
- Synovitis
- Joint disorder
- Peripheral neuropathy
- Mild hyperlipidemia
- Interstitial lung disease
- Vasculitis
Potentially Fatal:
- Hepatotoxicity
- Sepsis
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Pancreatitis
Warnings
Do not use Leflunomide in people with the following conditions:
- Liver disease
- Kidney disease
- Low immunity due to other illnesses
- Blood disorder
- Serious infections
- Hypoproteinemia
- Pregnant
- Lactation
Inform your doctor and pharmacist if you are taking any of these medicines:
- Rifampicin
- Methotrexate
- Tolbutamide
- Pioglitazone
- Repaglinide
- Indometacin
- Ketoprofen
- Duloxetine
- Warfarin
- Colestyramine
- Cimetidine
- Ciprofloxacin
- Cefaclor
- Tizanidine
Inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and non-prescription medicines.
This list does not include all medicines that may interact with Leflunomide.
How Does Leflunomide (Lefuheal 20 mg) 20 mg Work?
Leflunomide is an immunomodulating agent and disease-modifying antirheumatic drug (DMARD) that inhibits pyrimidine synthesis by inhibiting dihydroorotate dehydrogenase enzyme activity resulting in antiproliferative and anti-inflammatory effects.
Uses
Leflunomide is used to treat the following conditions:
- Rheumatoid arthritis; Psoriatic arthritis
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Mild renal impairment
- Patient with history of TB due to the possibility of reactivation of the infection
- Avoid caffeine-containing beverages such as coffee, tea, and certain soft drinks
- Avoid alcohol
Storage Conditions
- Store at 25°C.
- Store in a cool, dry place away from the reach of children. Protect from light.
- Do not use Leflunomide that is expired or out of date.
