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Cronotol 500 | Disulfiram 500 mg Tablet – 4 Tablets


Disulfiram (Cronotol 500) 500 mg tabletĀ is an aid used in the management of alcohol dependence. Once discontinued, it helps to establish self-motivation in maintaining abstinence from alcohol.

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Form Tabs
Usage/Application 4 Tabs
Brand Name Cronotol 500
Type Of Medicines Anti Alcoholic
Brand Healing Pharma India Pvt. Ltd.
Country of Origin Made in India

Disulfiram (Cronotol 500) 500 mg tabletĀ is an aid used in the management of alcohol dependence. Once discontinued, it helps to establish self-motivation in maintaining abstinence from alcohol.

Drug =Ā Disulfiram

Number of Pills Per Order =Ā  4

Strength = 500 mg

Manufacturer = Healing Pharma

How To Take

This medicine may be taken with or without food.

Do not take Disulfiram if you have consumed alcohol in the last 12 hours.

Take Disulfiram precisely as directed by your doctor or according to the instructions on the label. Do not take more than instructed by your doctor.


Adult: 800 mg as a single dose on the 1st day, reduced by 200 mg/day. Maintenance: 100-200 mg/day.

Missed Dose

If you miss a dose, skip the missed dose and return to your regular dosing schedule. If you often forget to take your medicine, let your doctor and pharmacist know.

Do not double a dose under any circumstances.


Signs of overdose may include the following:

  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Drowsiness
  • Delirium
  • Hallucinations
  • Lethargy
  • Tachycardia
  • Tachypnoea
  • Hyperthermia
  • Hypotension
  • Hypotonia
  • Hyperglycaemia
  • Leukocytosis
  • Ketosis
  • Methaemoglobinaemia
  • CV collapse
  • Coma and convulsions in severe cases


People with the following medical conditions should not take Disulfiram:

  • Cardiac failure
  • Coronary artery disease
  • History of stroke
  • Hypertension
  • Psychosis or severe personality disorders
  • Patients receiving metronidazole, paraldehyde, alcohol or alcohol-containing preparations (e.g., cough syrups, tonics)or alcohol-based topical preparations

Seek medical help immediately.

Side Effects

DisulfiramĀ may have the following side effects:

  • Drowsiness
  • Fatigue
  • Garlic-like or metallic aftertaste
  • Stomach upsets
  • Body odor
  • Halitosis
  • Headache
  • Impotence
  • Acneiform or allergic dermatitis
  • Peripheral and optic neuropathies
  • Psychotic reactions
  • Disulfiram-alcohol reaction (manifested by flushing of the face
  • Throbbing in the head and neck
  • Pulsating headache
  • Respiratorydifficulties
  • Nausea
  • Copious vomiting
  • Sweating
  • Thirst
  • Chest pain
  • Tachycardia
  • Palpitations
  • Marked hypotension
  • Giddiness
  • Weakness
  • Blurred vision
  • Confusion, and in severe cases
  • Resp depression
  • Cardiovascularcollapse
  • Cardiac arrhythmias
  • Heart attack
  • Acute heart failure
  • Unconsciousness
  • Convulsions, and sudden death
  • Rarely, blood dyscrasias

Potentially Fatal:

  • Severe hepatitis and hepatic failure


Do not use Disulfiram in people with the following conditions:

  • Allergic reactions to this medicine or any of its contents, and thiuram compounds such as those used rubber vulcanization and pesticides.
  • Heart failure
  • Blocked arteries in the heart
  • High blood pressure
  • Liver disease
  • History of stroke
  • Mental illness, e.g., severe personality disorder, thoughts of self-harm

Inform your doctor and pharmacist if you are taking or using any of these medicines:

  • Alcohol containing preparations
  • Aspirin
  • Warfarin
  • Amitriptyline
  • Chlorpromazine
  • Chlordiazepoxide
  • Diazepam
  • Phenytoin
  • Isoniazid
  • Rifampicin
  • Clarithromycin
  • Metronidazole

Inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and non-prescription medicines.

This list does not include all medicines that may interact with Disulfiram.

How Does It Work?

Disulfiram is an aldehyde dehydrogenase inhibitor, the oxidative enzyme of acetaldehyde, a metabolite of alcohol accumulated in the blood, thereby producing unpleasant symptoms of disulfiram-alcohol reaction when a patient has taken small amounts of alcohol.


DisulfiramĀ is used Ā to treat the following conditions:

  • Adjunct in chronic alcoholism

Special Precautions and Connected Warnings

Take special precautions if you have the following conditions:

  • Diabetes mellitus
  • Epilepsy
  • Respiratorydisorders
  • Cerebral damage
  • Hypothyroidism
  • Abnormal EEG results
  • Multiple drug dependence
  • Renal and hepatic impairment
  • Pregnancy and lactation
  • Avoid alcohol, avoid vinegar, cider, extracts and other food containing alcohol

Storage Conditions

  • Store at room temperature, away from excess heat and moisture
  • Store in a cool, dry place away from the reach of children.
  • Do not use Disulfiram that is expired or out of date.

Additional information

Dosage Type


Packaging Type

Number of Pills Per Order



Healing Pharma