| Form | Tabs |
| Usage/Application | 4 Tabs |
| Brand Name | Cronotol 500 |
| Type Of Medicines | Anti Alcoholic |
| Brand | Healing Pharma India Pvt. Ltd. |
| Country of Origin | Made in India |
Disulfiram (Cronotol 500) 500 mg tablet is an aid used in the management of alcohol dependence. Once discontinued, it helps to establish self-motivation in maintaining abstinence from alcohol.
Drug = Disulfiram
Number of Pills Per Order = 4
Strength = 500 mg
Manufacturer = Healing Pharma
How To Take
This medicine may be taken with or without food.
Do not take Disulfiram if you have consumed alcohol in the last 12 hours.
Take Disulfiram precisely as directed by your doctor or according to the instructions on the label. Do not take more than instructed by your doctor.
Dosage
Adult: 800 mg as a single dose on the 1st day, reduced by 200 mg/day. Maintenance: 100-200 mg/day.
Missed Dose
If you miss a dose, skip the missed dose and return to your regular dosing schedule. If you often forget to take your medicine, let your doctor and pharmacist know.
Do not double a dose under any circumstances.
Overdose
Signs of overdose may include the following:
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Drowsiness
- Delirium
- Hallucinations
- Lethargy
- Tachycardia
- Tachypnoea
- Hyperthermia
- Hypotension
- Hypotonia
- Hyperglycaemia
- Leukocytosis
- Ketosis
- Methaemoglobinaemia
- CV collapse
- Coma and convulsions in severe cases
Contraindications
People with the following medical conditions should not take Disulfiram:
- Cardiac failure
- Coronary artery disease
- History of stroke
- Hypertension
- Psychosis or severe personality disorders
- Patients receiving metronidazole, paraldehyde, alcohol or alcohol-containing preparations (e.g., cough syrups, tonics)or alcohol-based topical preparations
Seek medical help immediately.
Side Effects
Disulfiram may have the following side effects:
- Drowsiness
- Fatigue
- Garlic-like or metallic aftertaste
- Stomach upsets
- Body odor
- Halitosis
- Headache
- Impotence
- Acneiform or allergic dermatitis
- Peripheral and optic neuropathies
- Psychotic reactions
- Disulfiram-alcohol reaction (manifested by flushing of the face
- Throbbing in the head and neck
- Pulsating headache
- Respiratorydifficulties
- Nausea
- Copious vomiting
- Sweating
- Thirst
- Chest pain
- Tachycardia
- Palpitations
- Marked hypotension
- Giddiness
- Weakness
- Blurred vision
- Confusion, and in severe cases
- Resp depression
- Cardiovascularcollapse
- Cardiac arrhythmias
- Heart attack
- Acute heart failure
- Unconsciousness
- Convulsions, and sudden death
- Rarely, blood dyscrasias
Potentially Fatal:
- Severe hepatitis and hepatic failure
Warnings
Do not use Disulfiram in people with the following conditions:
- Allergic reactions to this medicine or any of its contents, and thiuram compounds such as those used rubber vulcanization and pesticides.
- Heart failure
- Blocked arteries in the heart
- High blood pressure
- Liver disease
- History of stroke
- Mental illness, e.g., severe personality disorder, thoughts of self-harm
Inform your doctor and pharmacist if you are taking or using any of these medicines:
- Alcohol containing preparations
- Aspirin
- Warfarin
- Amitriptyline
- Chlorpromazine
- Chlordiazepoxide
- Diazepam
- Phenytoin
- Isoniazid
- Rifampicin
- Clarithromycin
- Metronidazole
Inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and non-prescription medicines.
This list does not include all medicines that may interact with Disulfiram.
How Does It Work?
Disulfiram is an aldehyde dehydrogenase inhibitor, the oxidative enzyme of acetaldehyde, a metabolite of alcohol accumulated in the blood, thereby producing unpleasant symptoms of disulfiram-alcohol reaction when a patient has taken small amounts of alcohol.
Uses
Disulfiram is used to treat the following conditions:
- Adjunct in chronic alcoholism
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Diabetes mellitus
- Epilepsy
- Respiratorydisorders
- Cerebral damage
- Hypothyroidism
- Abnormal EEG results
- Multiple drug dependence
- Renal and hepatic impairment
- Pregnancy and lactation
- Avoid alcohol, avoid vinegar, cider, extracts and other food containing alcohol
Storage Conditions
- Store at room temperature, away from excess heat and moisture
- Store in a cool, dry place away from the reach of children.
- Do not use Disulfiram that is expired or out of date.
