| Packaging Size | 10 Tablets |
| Brand | Healing pharma |
| Salt Name | Losartan |
Losartan + Hydrochlorothiazide (Cozartan H) 50/ 12.5 mg tablet is a combination of two drugs that help keep your blood pressure under control. Losartan helps in reducing blood pressure by relaxing the blood vessels. Hydrochlorothiazide removes excess water and salts from the body through urination, thus reducing the amount of water in the body and lowering blood pressure.
Drug = Losartan + Hydrochlorothiazide
Number of Pills Per Order = 10
Strength = 50/ 12.5 Mg
Manufacturer = Healing Pharma
How To Take
This medicine may be taken with or without food. Try to take it at the same time each day.
Losartan + Hydrochlorothiazide must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take Losartan + Hydrochlorothiazide precisely as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Dosage
Adult: Per tab contains Losartan 50 mg and Hydrochlorothiazide 12.5 mg: 1 tab once daily. Up to 2 tabs once daily 2-4 weeks later if needed. Maximum of 2 tab/day.
Missed Dose
If you miss a dose, skip the missed dose and return to your usual dosing schedule. If you often forget to take your medicine, let your doctor and pharmacist know.
Do not double a dose under any circumstances.
Overdose
Signs of overdose may include the following:
- Hypotension
- Tachycardia
Seek medical help immediately.
Contraindications
People with the following medical conditions should not take Losartan + Hydrochlorothiazide:
- Pregnancy
- Lactation
- Intravascular volume depletion
Side Effects
Losartan + Hydrochlorothiazide may have the following side effects:
- Volume depletion and electrolyte imbalance (especially hyperkalemia)
- Dry mouth
- Thirst
- Lethargy
- Drowsiness
- Muscle pain and cramps
- Rashes
- Photosensitivity
- Thrombocytopenia
- Jaundice
- Pancreatitis
- Fatigue
- Weakness
- May precipitate an attack of gout impotence
- Hyperglycaemia
- Anorexia
- Nausea
- Vomiting
- Constipation
- Diarrhea
- Sialadenitis
- Raised urinary calcium concentration
- Headache
- Dizziness
- Back pain
- Myalgia
- First-dose hypotension
- Angioedema
- Neutropenia
- Gastrointestinaldisturbances
- Transient elevation of liver enzymes
- Taste disturbances
- Cough
- Exacerbation or activation of systemic lupus erythematous
- Palpitations
- Xanthopsia
- Leucopenia
- Agranulocytosis
- Aplastic anemia
- Necrotizing angiitis
- Glucosuria
- Renal dysfunction
- Interstitial nephritis
- Renal failure
- Migraine
- Hyponatremia
- UTI
- Chest pain
- Gastritis
- Weight gain
- Dyspepsia
- Abdominal pain
- Bronchitis
- Upper respiratory infection
- Nasal congestion
- Sinusitis
- Rise in cholesterol and triglycerides.
Potentially Fatal:
- Hypersensitivity reactions
- Hemolytic anemia
- Toxic epidermal necrolysis
Warnings
Do not use Losartan + Hydrochlorothiazide in people with the following conditions:
- Allergy to sulfonamide-derived medicines
- Unable to pass urine
Inform your doctor and pharmacist if you are taking any of these medicines:
- Aliskiren
- Digoxin
- Insulin
- Colestyramine
- Colestipol
- NSAIDs
- Lithium
- Potassium supplements
Inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and non-prescription medicines.
This list does not include all medicines that may interact with Losartan + Hydrochlorothiazide.
How Does It Work?
Hydrochlorothiazide increases renal sodium and chloride excretion and reduces the cardiac load. Losartan blocks the actions of angiotensin II of the renin-angiotensin-aldosterone system. This drug and its active metabolite selectively block the vasoconstrictor and aldosterone secreting effects of angiotensin II. The two drugs exert additive effects in hypertension.
Uses
Losartan + Hydrochlorothiazide is used to treat the following conditions:
- Hypertension
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Existing electrolyte disturbances
- Hepatic cirrhosis
- Severe hepatic failure
- Edema
- Elderly (>75 yr)
- Renal impairment
- Hepatic impairment
- Diabetes
- Gout
- Hyperlipidemia
- Hyperuricaemia
- ECG: LVH and ventricular ectopics extrasystoles)
- Volume depleted patients
- Patients on diuretics and salt restriction
- Renal artery stenosis
- Aortic and mitral stenosis
- Monitor potassium concentration
- Discontinue before performing tests for parathyroid function.
- Avoid alcohol.
- Cut down on your salt intake. This may help lower your blood pressure and improve your overall health. Speak to your doctor or dietitian about ways to cut down on your salt intake.
Storage Conditions
- Protect from light and store at 15-30 °C.
- Store in a cool, dry place away from the reach of children.
- Protect from light and moisture.
- Do not use Losartan + Hydrochlorothiazide that is expired or out of date.
