| Brand | Healing Pharma India Pvt Ltd |
| Manufacturer | Healing Pharma India Pvt Ltd |
| Composition | Fluconazole 50mg |
| Prescription/Non prescription | Prescription |
| Form | Tablet |
| Also gives | Third Party Manufacturing |
Fluconazole (Fluconaz 50) 50 mg tablet is an antifungal drug used to treat fungal infections in the skin and in other parts of the body.
Drug =Fluconazole
Number of Pills Per Order = 4
Strength = 50 mg.
Manufacturer = Healing Pharma
How To Take
This medicine may be taken with or without food. Try to make it at the same time each day.
Fluconazole is available as a tablet, capsule, or as a powder for oral suspension.
If you are taking the oral suspension, shake the bottle well before taking it to ensure that the liquid is evenly mixed. Use the measuring spoon or cup provided to measure your dose.
This medicine must be taken regularly for it to be effective. Continue taking Fluconazole even when you feel better.
Do not skip any doses. You must complete the entire course of medicine. If you don’t, the infection will not be properly controlled.
Take Fluconazole precisely as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Dosage of Fluconazole (Fluconaz 50) 50 mg
Adult: Oropharyngeal candidiasis: Treatment: Initially, 200-400 mg on Day 1, followed by 100-200 mg once daily for 7-21 days (until the disease is in remission). Prevention of relapse in patients with HIV: 100-200 mg once daily, or 200 mg 3 times a week.
Esophageal candidiasis: Treatment: Initially, 200-400 mg on Day 1, followed by 100-200 mg once daily for 14-30 days (until the disease is in remission). Prevention of relapse in patients with HIV: 100-200 mg once daily, or 200 mg 3 times a week.
Candiduria: 200-400 mg once daily for 7-21 days.
Chronic atrophic candidiasis: 50 mg once daily for 14 days.
Chronic mucocutaneous candidiasis: 50-100 mg once daily for up to 28 days.
Candidal balanitis; Vaginal candidiasis: 150 mg given as a single dose. Treatment and prevention of recurrent vaginal candidiasis (4 or more episodes a year): 150 mg every third day for a total of 3 doses (Day 1, 4, and 7), followed by a 150 mg once weekly maintenance dose (6 months).
Dermatophytosis; Tinea pedis, Tinea corporis, Tinea cruris, Candida infections: 150 mg once a week, or 50 mg once daily. Tinea versicolor: 300-400 mg once a week for 1-3 weeks, or 50 mg once daily for 2-4 weeks.
Invasive candidiasis: Initially, 800 mg on Day 1, followed by 400 mg once daily for two weeks.
Cryptococcal meningitis: Initially, 400 mg on Day 1, followed by 200-400 mg once daily, for at least 6-8 weeks. Prevention of relapse in patients with a high risk of recurrence: 200 mg once daily.
Coccidioidomycosis: 200-400mg once daily for 11-24 months or longer depending on the severity of infection, clinical or mycologic response.
Prevention of fungal infections in immunocompromised patients In patients with prolonged neutropenia: 200-400 mg once daily.
Missed Dose
If you miss a dose, skip the missed dose and return to your usual dosing schedule. If you often forget to take your medicine, let your doctor and pharmacist know.
Do not double a dose under any circumstances.
Overdose of Fluconazole (Fluconaz 50) 50 mg
Signs of overdose may include the following:
- Hallucination and paranoid behavior
Seek medical help immediately.
Contraindications
People with the following medical conditions should not take Fluconazole:
- Hypersensitivity
- Concomitant use with astemizole, cisapride, quinidine, terfenadine, pimozide and erythromycin
Side Effects
Fluconazole may have the following side effects:
- QT interval prolongation
- Rarely, anaphylaxis
- Agranulocytosis
- Anemia
- Leucopenia
- Thrombocytopenia
- Neutropenia
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Flatulence
- Dyspepsia
- Constipation
- Dry mouth
- Fatigue
- Malaise
- Asthenia
- Fever
- Angioedema
- Urticaria
- Hypercholesteremia
- Hypertriglyceridemia
- Hyperlipidemia
- Hypokalemia
- Anorexia
- Myalgia
- Headache
- Dizziness
- Dysgeusia
- Paresthesia
- Tremor
- Vertigo
- Insomnia
- Somnolence
- Rash
- Pruritus
- Increased sweating
- Alopecia
Potentially Fatal:
- Hepatic toxicity (e.g., cholestasis, hepatocellular damage, hepatitis, fulminant hepatic failure)
- Ventricular arrhythmia
- Torsade de Pointes
- Rarely, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Warnings
Inform your doctor and pharmacist if you are taking or using any of these medicines:
- Terfenadine
- Astemizole
- Erythromycin
- Cisapride
- Pimozide
- Quinidine
- Fentanyl
- Alfentanil
- Warfarin
- Glipizide
- Glimepiride
- Glyburide
- Rifampicin
- Halofantrine
- Zidovudine
- Saquinavir
- Simvastatin
- Atorvastatin
- Fluvastatin
- Amitriptyline
- Nortriptyline
- Carbamazepine
- Phenytoin
- Midazolam
- Triazolam
- Cyclophosphamide
- Vinca alkaloids
- Olaparib
- Ciclosporin
- Tacrolimus
- Celecoxib
- Naproxen
- Verapamil
- Nifedipine
- Amiodarone
Inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and non-prescription medicines.
This list does not include all medicines that may interact with Fluconazole.
How Does Fluconazole (Fluconaz 50) 50 mg Work?
Fluconazole is a triazole derivative antifungal agent that inhibits the demethylation of fungal CYP450 mediated 14 alpha-lanesterol, thereby reducing ergosterol biosynthesis, thus inhibiting fungal cell membrane formation.
Uses
Fluconazole is used to treat the following conditions:
- Oropharyngeal candidiasis
- Esophageal candidiasis
- Candiduria
- Chronic atrophic candidiasis
- Chronic mucocutaneous candidiasis
- Candidal balanitis
- Vaginal candidiasis
- Dermatophytosis
- Invasive candidiasis
- Cryptococcal meningitis
- Coccidioidomycosis
- Prevention of fungal infections in immunocompromised patients
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Patient with potentially proarrhythmic conditions (e.g., hypokalemia, electrolyte abnormality, advanced cardiac failure)
- Underlying severe disease (e.g., AIDS, malignancy)
- Renal and hepatic impairment
- Children and the elderly
- Pregnancy and lactation
- Avoid alcohol
Storage Conditions
- Store below 30°C
- Store in a cool, dry place away from the reach of children.
- Do not use Fluconazole that is expired or out of date.
