Sertraline (Sertafine 50) 50 mg tablet is a popular antidepressant medication used to treat depression. It can also be used to treat certain anxiety disorders such as social anxiety disorder, panic disorder, posttraumatic stress disorder, obsessive-compulsive disorder or OCD and premenstrual dysphoric disorder.
Drug =Sertraline
Number of Pills Per Order = 10
Strength = 50 mg
Manufacturer = Healing Pharma
How To Take
This medicine may be taken with or without food. Try to take it at the same time every day.
Your doctor will decide the dose of this medicine. Your doctor will advise you on the treatment time frame.
Sertraline must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed otherwise, as stopping it suddenly could worsen your condition.
Take Sertraline precisely as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Dosage of Sertraline (Sertafine 50) 50 mg
Adult: Depression: Initial: 50 mg once daily, may be increased, if necessary, in increments of 50 mg at intervals of at least one week. Maximum dose of 200 mg/day. Treatment duration: At least six months.
Obsessive-compulsive disorder: Initial: 50 mg once daily, may be increased, if necessary, in increments of 50 mg at intervals of at least one week. Maximum dose of 200 mg/day.
Panic disorder with or without agoraphobia; Posttraumatic stress disorder; Social anxiety disorder: Initial: 25 mg once daily, increased to 50 mg once daily after one week. Subsequent doses may be increased, if necessary, in increments of 50 mg at intervals of at least one week. Maximum dose of 200 mg/day.
Premenstrual dysphoric disorder: Continuous dosing: Initial: 50 mg once daily, may increase by 50 mg each menstrual cycle if necessary. Maximum dose of 150 mg/day. Luteal phase dosing: Initial: 50 mg once daily for the 1st three days, may increase by 100 mg/day. Maintenance: All doses must be given in the lowest effective dose, once the optimal response is achieved.
Missed Dose
If you miss a dose, skip the missed dose and return to your usual dosing schedule. If you often forget to take your medicine, let your doctor and pharmacist know.
Do not double a dose under any circumstances.
Overdose of Sertraline (Sertafine 50) 50 mg
Signs of overdose may include the following:
- Somnolence
- Dizziness
- Gastrointestinal disturbances (e.g. nausea, vomiting)
- Tachycardia
- Tremor
- Agitation
- QTc prolongation or Torsade de pointes on ECG
- Coma
Seek medical help immediately.
Contraindications
People with the following medical conditions should not take Sertraline:
- Concomitant use or within 14 days of discontinuation of MAOIs
- Concurrent use with pimozide
- Concomitant use of sertraline oral concentrate solution with disulfiram
Side Effects
Sertraline may have the following side effects:
- Activation of hypomania or mania
- Seizures
- Central nervous system depression
- QTc prolongation
- Torsade de pointes
- Abnormal bleeding events including cutaneous bleeding (e.g. ecchymoses, purpura)
- Bone fractures
- Mild pupillary dilation
- Sexual dysfunction
- Loss of glycemic control
- Withdrawal symptoms.
- Palpitations
- Chest pain
- Tinnitus
- Visual disturbance
- Nausea
- Diarrhea
- Dry mouth
- Dyspepsia
- Constipation
- Vomiting
- Abdominal pain
- Flatulence
- Gysgeusia
- Fatigue
- Malaise
- Asthenia
- Pyrexia
- Weight increased
- Decreased or increased appetite
- Back pain
- Arthralgia
- Myalgia
- Headache
- Dizziness
- Somnolence
- Paraesthesia
- Tremor
- Extrapyramidal symptoms (e.g. hyperkinesia, hypertonia, dystonia, teeth grinding or gait abnormalities)
- Disturbance in attention.
- Insomnia
- Anxiety
- Agitation
- Depression
- Nervousness
- Nightmare
- Bruxism
- Decreased libido
- Depersonalisation
- Ejaculation failure
- Erectile dysfunction
- Irregular menstruation
- Yawning
- Pharyngitis
- Rhinitis
- Upper respiratory tract infection
- Rash
- Hyperhidrosis
- Hot flush
Potentially Fatal:
- Suicidal thoughts and behaviour
- Serotonin syndrome or neuroleptic malignant syndrome (NMS)
- haemorrhage (e.g. gastrointestinal or gynaecological bleeding)
- Anaphylactoid reaction
- Angioedema
- Stevens-Johnson syndrome
- Erythema multiforme
- Vasculitis
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
- Hyponatraemia
Warnings
Inform your doctor and pharmacist if you are taking or using any of these medicines:
- Monoamine oxidase inhibitors
- Linezolid
- Pimozide
- Disulfiram
- Lithium
- Olanzapine
- Perphenazine
- Levomepromazine
- Sumatriptan
- Zolmitriptan
- Phenytoin
- Carbamazepine
- Phenobarbital
- Tolbutamide
- Glibenclamide
- Warfarin
- Ticlopidine
- Aspirin
- Ibuprofen
- St John’s wort
Inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and non-prescription medicines.
This list does not include all medicines that may interact with Sertraline.
How Does Sertraline (Sertafine 50) 50 mg Work?
Sertraline is a naphthalenamine-derivative antidepressant which selectively inhibits presynaptic reuptake of serotonin (5-HT). It has a very weak effect on norepinephrine and dopamine neuronal uptake.
Uses
Sertraline is used to treat the following conditions:
- Depression
- Obsessive-compulsive disorder
- Panic disorder with or without agoraphobia
- Posttraumatic stress disorder
- Social anxiety disorder
- Premenstrual dysphoric disorder
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Patients with a family history of bipolar disorder
- Mania or hypomania
- Schizophrenia
- Previous seizure disorder or condition predisposing to seizures (e.g. brain damage, alcoholism)
- Volume depletion
- Diabetes mellitus
- History of bleeding disorders
- Angle-closure glaucoma or history of glaucoma
- Risk factors for QTc prolongation
- Avoid abrupt withdrawal
- Hepatic impairment
- Children and the elderly
- Pregnancy and lactation
- CYP2C19 ultrarapid and poor metabolisers
- Avoid alcohol and excessive consumption of grapefruit juice (more than three glasses a day)
Storage Conditions
- Store between 20-25°C.
- Store in a cool, dry place away from the reach of children.
- Do not use Sertraline that is expired or out of date.
